The evidence, indexed
Every ingredient, with its studies.
Here are twenty-one supporting papers, all on file and readable in full.
Studied ingredients · 7
Also in the tablet
Calcium Carbonate (gentle abrasive) · Hydrated Silica (polishing agent) · Magnesium Stearate (tableting agent)
↑ ↓ moves through the list.
Active · five live cultures
Probiotic Blend
L. plantarum · L. rhamnosus · L. acidophilus · L. brevis · B. animalis
Five documented strains in one blend, the most studied component of the formula. The papers on file cover the oral microbiome and include studies in patients undergoing chemotherapy and radiation.
Supporting studies on file
Clinical Efficacy of Probiotics for Relieving Cold Symptoms in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Nutrients, 2025 · Lungaro et al.
“The probiotic mix effectively alleviated cold symptoms and reduced pro-inflammatory cytokine levels, suggesting anti-inflammatory effects.”
Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review
Dentistry Journal, 2024 · D'Agostino et al.
“Several studies agreed on the potential of probiotics L. rhamnosus and L. plantarum, both alone and combined, to prevent and improve clinical outcomes in caries and periodontal treatments, weaker evidence is provided for the microbiological benefit.”
The role of Lactobacillus plantarum in oral health: a review of current studies
Journal of Oral Microbiology, 2024 · Huang et al.
“In general, the utilization of L. plantarum in managing non-communicable biofilmdependent oral diseases is promising, but additional investigations are warranted.”
Probiotics in the management of radiation-induced oral mucositis
Frontiers in Cellular and Infection Microbiology, 2024 · Li et al.
“Therefore, approaches that modulate oral microbial ecology are promising for the management of RIOM.”
Health-Promoting Effects of Lactobacillus acidophilus and Its Technological Applications in Fermented Food Products and Beverages
Fermentation, 2024 · Liu et al.
“This review discusses the health benefits of L. acidophilus, including its ability to enhance immunity; promote digestive wellness; and exhibit antioxidant, antitumor, and antimicrobial properties.”
Probiotics for the Management of Oral Mucositis: An Interpretive Review of Current Evidence
Advanced Pharmaceutical Bulletin, 2023 · Fallah et al.
“While animal studies have reported protective effects of probiotics on oral mucositis, the evidence from human studies is not convincing.”
Lactobacillus Probiotics and their Impact on Periodontal Diseases
EAS Journal of Dentistry and Oral Medicine, 2023 · Hurtado-Camarena et al.
“They have even been shown to be effective in periodontal diseases by controlling the growth of etiological agents and reducing the inflammation of the tissues affected by periodontal diseases.”
Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10
International Journal of Oral Science, 2023 · Li et al.
“This study investigated the effect of sunitinib on oral mucosal healing impairment in mice and the therapeutic potential of Bifidobacterium breve (B. breve).”
Paraprobiotics: definition, manufacturing methods, and functionality
Food Science and Biotechnology, 2023 · Lee et al.
“Therefore, this review summarizes and discusses the manufacturing methods and bioavailability of paraprobiotics and suggests their potential health advantages.”
A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma
Frontiers in Immunology, 2021 · Xia et al.
“We found that patients taking the probiotic cocktail showed significantly lower OM.”
Lactobacillus brevis CD2 for Prevention of Oral Mucositis in Patients With Head and Neck Tumors: A Multicentric Randomized Study
Anticancer Research, 2019 · De Sanctis et al.
“Our study was not able to demonstrate the efficacy of L. brevis CD2 lozenges in preventing radiation-induced mucositis in patients with head and neck cancer.”
Characterization of a Lactobacillus brevis strain with potential oral probiotic properties
BMC Microbiology, 2018 · Fang et al.
“L. brevis BBE-Y52 exhibited a spectrum of probiotic properties, which may facilitate its applications in oral care products.”
Lactobacillus brevis CD2 lozenges prevent oral mucositis in patients undergoing high dose chemotherapy followed by haematopoietic stem cell transplantation
ESMO Open, 2017 · Sharma et al.
“Promising results from the study encourage the use of L. brevis CD2 lozenges as a supportive care treatment option.”
Studies are provided for professional reference and describe research on individual ingredients, not on Oral-Regen as a finished product.